Anti-Hu CD3 Purified

Product code: 30-2800

Clone name : UCHT1
Clonality : Monoclonal
Application : FACS

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Purification : Purified by protein-A affinity chromatography.
Content : Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD3E
Gene ID : 916
Uniprot ID : P07766
Alternative Name : CD3 antigen, epsilon polypeptide CD3E, T3E, TCRE
Immunogen Information : human thymocytes followed by Sezary T cells

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Specificity :The antibody UCHT1 recognizes an extracellular epitope on CD3 antigen of the TCR/CD3 complex on mature human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex.

Immunocytochemistry and immunohistochemistry (frozen sections): The epitope for UCHT1 is resistant to fixation.
Flow cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 µg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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