Anti-HSP47 Monoclonal Antibody (Clone : 1C4-1A6) - APC
Figure1 : Mouse Anti-Hsp47 Antibody [1C4-1A6] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked HeLa Cells
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| Amount : | 200 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Purified |
| Content : | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Storage condition : | Store the antibody at 4°C |
HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions.
The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate. Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils.
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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