Anti-HLA-DQ (MHC II) Monoclonal Antibody(Clone: SPM422)
Fig. 1: Flow Cytometric Analysis of Raji cells. HLA-DQ Mouse Monoclonal Antibody (SPM422) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
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Shipping Info:
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2a, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | HLA-DQ |
| Gene ID : | 3117; 3118; 3119 |
| Uniprot ID : | P01908; P01909; P01920 |
| Alternative Name : | CELIAC1; DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE); HLA Class II DQ; HLA class II histocompatibility antigen DQ; HLA class II histocompatibility antigen DQ(1) alpha chain; HLA class II histocompatibility antigen DQ(3) alpha chain; HLA DQA1; HLA DQB; HLA DQB1; IDDM1; Leucocyte antigen DQA1; Major histocompatibility complex class II DQ alpha 1; Major histocompatibility complex class II DQ beta 1; MHC class II antigen HLA DQ beta 1; MHC class II HLA DQ alpha 1; MHC class II HLA DQ beta glycoprotein; MHC DQ beta; MHC HLA DQ alpha |
| Immunogen Information : | T4-positive CTL clone HG-38 |
Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
ELISA (For coating, order antibody without BSA); Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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