Anti-Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker) Monoclonal Antibody(Clone: NRG1/2710)

Fig. 1: Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710).

Anti-Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker) Monoclonal Antibody(Clone: NRG1/2710)

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Fig. 1: Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710).

Fig. 2: SDS-PAGE Analysis Purified Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710). Confirmation of Purity and Integrity of Antibody.

Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-2468

Clone name :	NRG1/2710
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG1, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	NRG1
Gene ID :	3084
Uniprot ID :	Q02297
Alternative Name :	Acetylcholine receptor-inducing activity (ARIA); Breast cancer cell differentiation factor p45; Glial growth factor (GGF2); Heregulin-1; Heregulin, alpha (45kD, ERBB2 p185-activator); HGL; HRG1; HRGA; MST131; Neu Differentiation Factor (NDF); Neuregulin-1; NRG1; Sensory and Motor Neuron-Derived Factor (SMDF)
Immunogen Information :	Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene throÂµgh alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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