Anti-Henipavirus (Clone: HENV-117)

Product code: 12-8123

Clone name : HENV-117
Clonality : Monoclonal
Application : FACS

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100 µg
$499.00 

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Amount : 100 µg
Isotype : Human IgG1
Purification : ≥95% monomer by analytical SEC
Content : ≥ 5.0 mg/ml. This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Storage condition : Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -70°C. Avoid Repeated Freeze Thaw Cycles.
Immunogen Information : HENV-117 was isolated from circulating B cells of an individual exposed to equine HeV vaccine.
Reactivity Species : Henipavirus⋅Virus
Expression Host : HEK-293
Endotoxin Level : ≤ 1.0 EU/mg as determined by the LAL method
Specificity: HENV-117 activity is directed against the receptor-binding domain of receptor binding protein (RBP). HENV-117, has shown to neutralizes HeV, NiVM, or NiVB with exceptional potency according to the literature and HENV-117 maps to the receptor-binding domain of HeV-RBP and displays a receptor-blocking phenotype. Binding decreases substantially in the presence of ephrin-B2, indicating HENV-117 neutralizes by blocking binding of virus to host cells. nsEM mapping shows that HENV-117 mimics ephrin-B2 binding.
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