Anti-Grb2 Polyclonal Antibody
Figure 1: Western Blotting analysis (reducing conditions) of Ramos cell lysate using two batches of rabbit anti-Grb2 polyclonal (A, B).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from rabbit serum by affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
Western Blotting Recommended dilution: 1 µg/ml
Positive control: RAMOS human Burkitt lymphoma cell line
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Endosome, Golgi apparatus |
| BioGrid: | 109142. 543 interactions. |
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