Anti-GRAP2/GADS Monoclonal Antibody (Clone:UW40)

Product code: 30-1448

Clone name : UW40
Clonality : Monoclonal
Application : FACS, IP, WB
Reactivity : Human

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : GRAP2
Gene ID : 9402
Uniprot ID : O75791
Alternative Name : GRAP2, GADS, GRB2L, GRID
Immunogen Information : GST-fusion human GRAP2/GADS protein
GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.

Flow Cytometry Recommended dilution:1 µg/ml
Immunoprecipitation Western Blotting

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Cytoplasm, Endosome
BioGrid: 114799. 49 interactions.
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