Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Monoclonal Antibody(Clone: GZMB/3014)

Name: Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Monoclonal Antibody(Clone: GZMB/3014)
Brand: Abeomics
SKU: 36-2450
Price: 520.0000 USD
Availability: InStock
Rating: 4.2 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human Spleen stained with Granzyme B Monospecific Mouse Monoclonal Antibody (GZMB/3014).

Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Monoclonal Antibody(Clone: GZMB/3014)

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Fig. 1: Formalin-fixed, paraffin-embedded human Spleen stained with Granzyme B Monospecific Mouse Monoclonal Antibody (GZMB/3014).

Fig. 2: Formalin-fixed, paraffin-embedded human Tonsil stained with Granzyme B Monospecific Mouse Monoclonal Antibody (GZMB/3014).

Fig. 3: SDS-PAGE Analysis Purified Granzyme B Mouse Monoclonal Antibody (GZMB/3014). Confirmation of Integrity and Purity of Antibody.

Fig. 4: Western Blot Analysis of spleen tissue lysate using Granzyme B Mouse Monoclonal Antibody (GZMB/3014).

Fig. 5: Analysis of Protein Array containing >19,000 full-length human proteins using Granzyme B Monospecific Mouse Monoclonal Antibody (GZMB/3014) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-2450

Clone name :	GZMB/3014
Clonality :	Monoclonal
Application :	WB, IHC
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	GZMB
Gene ID :	3002
Uniprot ID :	P10144
Alternative Name :	Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; GRB; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E
Immunogen Information :	Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thoÂµght to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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