Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Monoclonal Antibody(Clone: GZMB/2403)
Fig. 1: SDS-PAGE Analysis Purified Granzyme B Mouse Monoclonal Antibody (GZMB/2403). Confirmation of Integrity and Purity of Antibody.
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Shipping Info:
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Amount : | 100 µg |
Isotype : | Mouse IgG2b, lambda |
Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
Gene : | GZMB |
Gene ID : | 3002 |
Uniprot ID : | P10144 |
Alternative Name : | Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E |
Immunogen Information : | Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary) |
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thoµght to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.
ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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