Anti-GABA B receptor GB1b subunit Polyclonal Antibody(Discontinued)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from rabbit serum by affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
| Immunogen Information : | Synthetic peptide (coupled with THG) derived from amino acid sequence 30-47 of mouse GABA B receptor 1b. Only 1 amino acid is different from immunogen derived from human GB1b. |
GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain.
Western Blotting Recommended dilution: 2 µg/ml
Immunocytochemistry
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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