Anti-FoxP3 Monoclonal Antibody (Clone:3G3)-APC Conjugated

Product code: 30-1762

Clone name : 3G3
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human, Mouse
Conjugate : APC

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Size
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0.1 mg
$520.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : FOXP3
Gene ID : 50943
Uniprot ID : Q9BZS1
Alternative Name : FOXP3, IPEX, JM2
Immunogen Information : Full-length His-tagged recombinant murine FoxP3
FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.
Subcellular location: Nucleus, Cytoplasm
Post transnational modification: Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites.
BioGrid: 119170. 70 interactions.
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