Anti-FOXP3 (Forkhead Box Protein P3) / Scurfin Monoclonal Antibody(Clone: 3G3)

Product code: 36-2901

Clone name : 3G3
Clonality : Monoclonal
Application : FACS, IF
Reactivity : Human, Mouse

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Available Pack Size(s)

  •   20 µg

  •  100 µg

  • $270.00 

  • $520.00 

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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : FOXP3
Gene ID : 50943
Uniprot ID : Q9ZS1
Alternative Name : JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7, forkhead box protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin
Immunogen Information : Full-length His-tagged Mouse FOXP3 protein
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription throµgh a DNA binding forkhead domain, thereby regulating T cell activation.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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