Anti-Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody(Clone: ESR1/3559)

Name: Anti-Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody(Clone: ESR1/3559)
Brand: Abeomics
SKU: 36-2254
Price: 520.0000 USD
Availability: InStock
Rating: 5 (10 reviews)

Fig. 1: SDS-PAGE Analysis Purified Estrogen Receptor alpha Mouse Monoclonal Antibody (ESR1/3559). Confirmation of Integrity and Purity of Antibody.

Anti-Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody(Clone: ESR1/3559)

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Fig. 1: SDS-PAGE Analysis Purified Estrogen Receptor alpha Mouse Monoclonal Antibody (ESR1/3559). Confirmation of Integrity and Purity of Antibody.

Fig. 2: Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Estrogen Receptor alpha Mouse Monoclonal Antibody (ESR1/3559).

Fig. 3: Flow Cytometric Analysis of MCF-7 cells using Estrogen Receptor alpha Mouse Monoclonal Antibody (ESR1/3559) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Fig. 4: Analysis of Protein Array containing more than 19,000 full-length human proteins using Estrogen Receptor alpha Mouse Monoclonal Antibody (ESR1/3559) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-2254

Clone name :	ESR1/3559
Clonality :	Monoclonal
Application :	FACS, IHC
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	ESR1
Gene ID :	2099
Uniprot ID :	P03372
Alternative Name :	Estrogen Receptor alpha delta 45,6,7/654 isoform; Estrogen Receptor alpha delta 4 +49 isoform; Nuclear receptor subfamily 3 group A member 1
Immunogen Information :	Recombinant human ESR1 protein fragment (around aa129-312) (exact sequence is proprietary)

This monoclonal antibody is specific to estrogen receptor alpha (ER alpha) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

Flow Cytometry (1-2ug/million cells);,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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