Anti-ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody(Clone: ESR2/3005)
Fig. 1: SDS-PAGE Analysis Purified ER-beta Mouse Monoclonal Antibody (ESR2/3005). Confirmation of Purity and Integrity of Antibody.
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2c, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | ESR2 |
| Gene ID : | 2100 |
| Uniprot ID : | Q92731 |
| Alternative Name : | Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4 |
| Immunogen Information : | Recombinant full-length human ESR2 protein |
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, thoµgh some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence sµggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even thoµgh they share many functional characteristics.
ELISA (For coating, order Ab without BSA);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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