Anti-Ep-CAM / CD326 (Extracellular Domain) (Epithelial Marker) Monoclonal Antibody(Clone: Ber-EP4)
Fig. 1: Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Ep-CAM Mouse Monoclonal Antibody (Ber-EP4)
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| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1, kappa |
| Content : | Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format. |
| Storage condition : | Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | TACSTD1 |
| Gene ID : | 4072 |
| Uniprot ID : | P16422 |
| Alternative Name : | Adenocarcinoma-associated Antigen; Cell Surface Glycoprotein Trop-1; EGP2; EGP314; EGP40; Epithelial Cell Adhesion Molecule; Epithelial Glycoprotein 314; ESA; KSA; TACD1; TACSTD1; TROP1; Tumor-associated Calcium Signal Transducer 1 |
| Immunogen Information : | Human breast cancer MCF-7 cells |
Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. It has been reported that this epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been sµggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.
Flow Cytometry (0.5-1ug/million cells); Immunohistochemistry (Formalin-fixed) (1:100-1:200 for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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