PE Conjugated, Anti-Drebrin Monoclonal Antibody (Clone:DBN-N-03)

Product code: 30-2339

Clone name : DBN-N-03
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG2b
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : DBN1
Gene ID : 1627
Uniprot ID : Q16643
Alternative Name : Developmentally-regulated brain protein
Immunogen Information : Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.

Subcellular location: Cytoplasm, Cell projection, Cytoplasm, Cell junction, Cell projection
Post transnational modification: Degraded by caspases during apoptosis.
Tissue Specificity: Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578). Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400). Expressed in the brain (PubMed:8216329, Ref.2). Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2).
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