Anti-DLL4 Monoclonal Antibody (Clone:MHD4-46) Purified
Figure 1: Separation of DLL4 transfected HD4 cells stained using anti-DLL4 (MHD4-46) purified antibody (GAM APC, red-filled) from DLL4 transfected HD4 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Flow Cytometry Functional Application blocking
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | Expressed in vascular endothelium. |
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