Anti-Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker) Monoclonal Antibody(Clone: KRT5/2080)
Fig. 1: Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cytokeratin 5 (KRT5) Mouse Monoclonal Antibody (KRT5/2080).
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| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1, kappa |
| Content : | Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format. |
| Storage condition : | Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | KRT5 |
| Gene ID : | 3852 |
| Uniprot ID : | P13647 |
| Alternative Name : | 58kDa Cytokeratin; CK5; Cytokeratin-5; DDD1; Epidermolysis Bullosa Simplex 2 (EBS2); Keratin 5; Keratin, Type II Cytoskeletal 5; Keratin-5; KRT5; Type-II Cytoskeletal 5; Type-II keratin Kb5 |
| Immunogen Information : | Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491) (exact sequence is proprietary) |
This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express.Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.
Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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