Anti-Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) Monoclonal Antibody(Clone: CCND1/3548)
Fig. 1: SDS-PAGE Analysis Purified Cyclin D1 Mouse Monoclonal Antibody (CCND1/3548). Confirmation of Purity and Integrity of Antibody.
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2b, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | CCND1 |
| Gene ID : | 595 |
| Uniprot ID : | P24385 |
| Alternative Name : | B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene |
| Immunogen Information : | Recombinant fragment of human CCND1 (around aa 115-270) protein (exact sequence is proprietary) |
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
ELISA (For coating, order Ab without BSA);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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