Anti-Cyclin B1 (G2- & M-phase Cyclin) Monoclonal Antibody(Clone: CCNB1/2978R)(Discontinued)

Product code: 36-3444

Clone name : CCNB1/2978R
Clonality : Monoclonal
Application : ELISA
Reactivity : Human

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Amount : 100 µg
Isotype : Rabbit IgG
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : CCNB1
Gene ID : 891
Uniprot ID : P14635
Alternative Name : CCNB, CCNB1, CCNB1_HUMAN, G2 Mitotic Specific Cyclin B1
Immunogen Information : Recombinant full-length human CCNB1 protein

It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

ELISA (For coating, order Ab without BSA); Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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