Anti-CTLA4 / CD152 (Negative Regulator of T-Cells) Monoclonal Antibody(Clone: L4P2F5.F10)
Fig. 1: SDS-PAGE Analysis of Purified CTLA4 Mouse Monoclonal Antibody (L4P2F5.F10). Confirmation of Purity and Integrity of Antibody
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | CTLA4 |
| Gene ID : | 1493 |
| Uniprot ID : | P16410 |
| Alternative Name : | ALPS5; CD152; Celiac disease 3 (CELIAC3); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4); GRD4; GSE; ICOS; Insulin-dependent Diabetes Mellitus 12 (IDDM12) |
| Immunogen Information : | A synthetic peptide from CTLA4 (exact sequence is proprietary) |
CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
Flow Cytometry (1-2ug/million cells); ,Immunofluorescence (1-2ug/ml); ,Western Blot (1-2ug/ml); ,
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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