Anti-Csk Monoclonal Antibody (Clone:CSK-04)
Figure 1: Immunofluorescence staining of Csk in human HeLa cell line using anti-Csk (CSK-04; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
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| Format : | Purified |
| Amount : | 0.1 ml |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases that are localized in lipid rafts is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.
| Subcellular location: | Cytoplasm, Cell membrane |
| Post transnational modification: | Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. |
| Tissue Specificity: | Expressed in lung and macrophages. |
| BioGrid: | 107832. 58 interactions. |
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