Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb

Product code: 12-9549

Clone name : 1H2
Clonality : Monoclonal
Application : ELISA
Reactivity : N.A.

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Available Pack Size(s)

  •   10 µg

  •   100 µg

  • $355.00 

  • $637.00 

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For estimated delivery dates, please contact us at [email protected]


Amount : 100 µg
Isotype : Rabbit IgG
Purification : Purified from cell culture supernatant by affinity chromatography
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage condition : Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Description :Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb
CL2A is a crucial component in antibody-drug conjugate (ADC) therapy, acting as a chemical linker that connects a potent DNA topoisomerase I inhibitor, SN-38, to an antibody. Representing Cysteine-Linked 2-Aminoethyl, CL2A features a complex structure with a PEG8 chain, a triazole ring, a PABC-peptide, and a maleimide group. The maleimide group binds to a cysteine residue on the antibody, facilitating targeted drug delivery. Designed to release SN-38 in acidic cancer cell environments, CL2A induces DNA damage and cell death. This versatile linker is employed in ADCs targeting various antigens like Trop-2 or HER2, tailored to specific cancer types.

ELISA 1:5000-10000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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