Anti-Chromogranin A / CHGA (Neuroendocrine Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCHGA/413)

Figure 1: Formalin-fixed, paraffin-embedded Human Pancreas stained with Chromogranin A Mouse Recombinant Monoclonal Antibody (rCHGA/413).

Anti-Chromogranin A / CHGA (Neuroendocrine Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCHGA/413)

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Figure 1: Formalin-fixed, paraffin-embedded Human Pancreas stained with Chromogranin A Mouse Recombinant Monoclonal Antibody (rCHGA/413).

Figure 2: SDS-PAGE Analysis of Purified Chromogranin A Mouse Recombinant Monoclonal Antibody (rCHGA/413).

Figure 3:Analysis of Protein Array containing >19,000 full-length human proteins using Chromogranin A Recombinant Mouse Monoclonal Antibody (rCHGA/413) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 12-1143

Clone name :	rCHGA/413
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS / Manual MSDS

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Purification :	Protein A/G
Content :	200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	CHGA
Gene ID :	1113
Uniprot ID :	P10645
Alternative Name :	Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II
Immunogen Information :	Recombinant full-length human CHGA protein

Chromogranin A is present in neuroendocrine cells throµghout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Immunohistochemistry (Formalin-fixed) (0.25-0.5µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted, Cytoplasmic vesicle
Post transnational modification:	Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).
Tissue Specificity:	GE-25 is found in the brain.
BioGrid:	107538. 12 interactions.