Anti-CD9 Monoclonal Antibody (Clone:MEM-61)

CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.

Flow Cytometry Recommended dilution: 5 µg/ml
Western Blotting Recommended dilution: 2-4 µg/ml
Immunohistochemistry Recommended dilution: 20 µg/ml
Positive tissue: prostate
Mass Cytometry Functional Application The antibody MEM-61 induces FcgammaR-dependent platelet aggregation.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Membrane, Cell membrane
Post transnational modification:	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
Tissue Specificity:	Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.
BioGrid:	107366. 23 interactions.

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