Anti-CD9 Monoclonal Antibody (Clone:MEM-61)-Biotin Conjugated
Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD9 (MEM-61) Biotin antibody (concentration in sample 1 μg/ml, Streptavidin APC).
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.
| Subcellular location: | Membrane, Cell membrane |
| Post transnational modification: | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. |
| Tissue Specificity: | Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells. |
| BioGrid: | 107366. 23 interactions. |
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