Anti-CD9 Monoclonal Antibody (Clone:EM-04)-Biotin Conjugated
Figure 1: Detection of CD9 in bone marrow-derived mast cell (BMMC) lysates by rat monoclonal EM-04 antibody.
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG1 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.
| Subcellular location: | Membrane, Cell membrane, Secreted |
| Post transnational modification: | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity). |
| Tissue Specificity: | Expressed predominantly in the peripheral nervous system. |
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