Anti-CD8b Monoclonal Antibody (Clone:341)-PE Conjugated

Product code: 30-2310

Clone name : 341
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, Functional Assay
Reactivity : Rat
Conjugate : PE

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0.1 mg
$433.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : Cd8b
Gene ID : 24931
Uniprot ID : P05541
Alternative Name : Cd8b, Cd8b1, CD8 antigen 37 kDa chain, OX-8 membrane antigen
Immunogen Information : CD8 positive Wistar rat splenic T cell hybridomas
The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Subcellular location: Cell membrane
Post transnational modification: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
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