Anti-CD8a Monoclonal Antibody (Clone:OX-8)

Product code: 30-1482

Clone name : OX-8
Clonality : Monoclonal
Application : FACS
Reactivity : Rat

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0.1 mg
$363.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Cd8a
Gene ID : 24930
Uniprot ID : P07725
Alternative Name : Cd8a
Immunogen Information : High Mw glycoproteins from rat thymocytes

The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Flow Cytometry Immunoprecipitation Western Blotting Immunohistochemistry Immunohistochemistry (frozen sections) Functional Application blocking

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
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