Anti-CD8a Monoclonal Antibody (Clone:53-6.7)-Low Endotoxin

Product code: 30-1623

Clone name : 53-6.7
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse

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0.1 mg
$345.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Rat IgG2a
Purification : Purified by protein-G affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Cd8a
Gene ID : 12525
Uniprot ID : P01731
Alternative Name : Cd8a, Lyt-2, Lyt2, Ly-2, Ly-B, Ly-35, Lyt-2, BB154331
Immunogen Information : Mouse spleen cells

The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Flow Cytometry Recommended dilution:1.5 µg/ml
Immunoprecipitation Immunohistochemistry Immunohistochemistry (frozen sections) Recommended dilution: 1:1000
Application note: Formaldehyde fixation is not recommended, acetone fixation is preferred.
Immunocytochemistry Functional Application Isolation and depletion of CD8+ cells, blocking of cytotoxicity, inhibition of CD8+ T cell proliferation.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
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