Anti-CD8a Monoclonal Antibody (Clone:53-6.7)-FITC Conjugated

Product code: 30-2039

Clone name : 53-6.7
Clonality : Monoclonal
Application : FACS, IP, IHC, IHC-Fr, ICC, Functional Assay
Reactivity : Mouse
Conjugate : FITC

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0.1 mg
$363.00 

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Amount : 0.1 mg
Isotype : Rat IgG2a
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : Cd8a
Gene ID : 12525
Uniprot ID : P01731
Alternative Name : Cd8a, Lyt-2, Lyt2
Immunogen Information : Mouse spleen cells
The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
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