Anti-CD88 / C5aR Monoclonal Antibody (Clone:S5/1)Purified

Product code: 30-1531

Clone name : S5/1
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : C5AR1
Gene ID : 728
Uniprot ID : P21730
Alternative Name : C5AR1, C5AR, C5R1
Immunogen Information : Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR

CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.

Subcellular location: Cell membrane, Cytoplasmic vesicle
Post transnational modification: Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.
BioGrid: 107189. 5 interactions.
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