Anti-CD86 Monoclonal Antibody (Clone:GL-1)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rat IgG2a |
| Purification : | Purified by protein-G affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Flow Cytometry Recommended dilution: 2 µg/ml
Positive control:mouse splenocytes
Immunoprecipitation Immunohistochemistry (frozen sections) Immunocytochemistry Functional Application Blocking
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Tissue Specificity: | Expressed on activated B-cells. |
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