Anti-CD86 Monoclonal Antibody (Clone:BU63)-PE Conjugated

Product code: 30-2257

Clone name : BU63
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, Functional Assay
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD86
Gene ID : 942
Uniprot ID : P42081
Alternative Name : CD86, CD28LG2
Immunogen Information : B-lymphoblastoid cell line ARH 77
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Subcellular location: Cell membrane
Post transnational modification: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Tissue Specificity: Expressed by activated B-lymphocytes and monocytes.
BioGrid: 107380. 6 interactions.
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