Anti-CD85j / ILT2 Monoclonal Antibody (Clone:GHI/75)-Low Endotoxin

Product code: 30-1653

Clone name : GHI/75
Clonality : Monoclonal
Application : FACS, IP, WB, Functional Assay
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : LILRB1
Gene ID : 10859
Uniprot ID : Q8NHL6
Alternative Name : LILRB1, ILT2, LIR1, MIR7
Immunogen Information : Hairy cell leukaemia cells
CD85j, also known as ILT-2 (Ig-like transcript 2), LIR-1 (leukocyte Ig-like receptor 1), or LILRB1 (leukocyte Ig-like receptor B1), is a member of Ig superfamily transmembrane glycoproteins named CD85. The CD85j protein is expressed on several types of immune cells (plasma cells, B cells, monocytes, T and NK cell subsets) where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

Flow Cytometry Immunoprecipitation Western Blotting Functional Application blocking HLA-G induced TGF-beta1 production

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Tissue Specificity: Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
BioGrid: 116070. 7 interactions.
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