Anti-CD85j / ILT2 Monoclonal Antibody (Clone:GHI/75)-PE Conjugated
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD85j, also known as ILT-2 (Ig-like transcript 2), LIR-1 (leukocyte Ig-like receptor 1), or LILRB1 (leukocyte Ig-like receptor B1), is a member of Ig superfamily transmembrane glycoproteins named CD85. The CD85j protein is expressed on several types of immune cells (plasma cells, B cells, monocytes, T and NK cell subsets) where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
| Subcellular location: | Secreted |
| Post transnational modification: | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Tissue Specificity: | Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells. |
| BioGrid: | 116070. 7 interactions. |
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