Anti-CD83 Monoclonal Antibody (Clone:HB15e)
Figure 1: Flow cytometry surface staining pattern of human interferon alpha stimulated peripheral whole blood stained using anti-human CD83 (HB15e) purified antibody (concentration in sample 2 μg/ml, GAM APC).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD83 is a 40-45 kDa heavily glycosylated type I cell surface glycoprotein of immunoglobulin family. It is expressed on the surface of mature dendritic cells, Langerhans cells in the skin, and interdigitating reticulum cells in the lymphoid tissues. Low expression of CD83 has been reported in activated T and B cells. Cytoplasmic expression of CD83 can be detected also in monocytes and macrophages. CD83 is involved in modulation of antigen presentation. Soluble CD83 has immunoregulatory functions, it is able to down-regulate dendritic cell maturation and stimulation of T cells. In the developing immune system, release of soluble CD83 from dendritic cells upon stimulation by gram-positive or gram-negative bacteria has anti-allergic effect. Herpes simplex virus, on the other hand, causes CD83 degradation in mature dendritic cells.
Flow Cytometry Positive control:peripheral blood-derived dendritic cells
Immunohistochemistry (frozen sections) Application note:acetone fixation
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| Tissue Specificity: | Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. |
| BioGrid: | 114721. 51 interactions. |
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