Anti-CD83 Monoclonal Antibody (Clone:HB15e)-PE Conjugated

Product code: 30-2329

Clone name : HB15e
Clonality : Monoclonal
Application : FACS, IHC-Fr
Reactivity : Human, Non-Human Primates
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD83
Gene ID : 9308
Uniprot ID : Q01151
Alternative Name : CD83
Immunogen Information : Human CD83-transfected Cos cells
CD83 is a 40-45 kDa heavily glycosylated type I cell surface glycoprotein of immunoglobulin family. It is expressed on the surface of mature dendritic cells, Langerhans cells in the skin, and interdigitating reticulum cells in the lymphoid tissues. Low expression of CD83 has been reported in activated T and B cells. Cytoplasmic expression of CD83 can be detected also in monocytes and macrophages. CD83 is involved in modulation of antigen presentation. Soluble CD83 has immunoregulatory functions, it is able to down-regulate dendritic cell maturation and stimulation of T cells. In the developing immune system, release of soluble CD83 from dendritic cells upon stimulation by gram-positive or gram-negative bacteria has anti-allergic effect. Herpes simplex virus, on the other hand, causes CD83 degradation in mature dendritic cells.
Subcellular location: Membrane
Tissue Specificity: Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.
BioGrid: 114721. 51 interactions.
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