Anti-CD80 / B7-1 Monoclonal Antibody (Clone:MEM-233)-FITC Conjugated

Product code: 30-1971

Clone name : MEM-233
Clonality : Monoclonal
Application : FACS, IP
Reactivity : Human
Conjugate : FITC

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100 tests
$433.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD80
Gene ID : 941
Uniprot ID : P33681
Alternative Name : CD80, CD28LG, CD28LG1, LAB7
Immunogen Information : Extracellular domain of human CD80 fused to human IgG1(Fc)
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Subcellular location: Membrane
Tissue Specificity: Expressed on activated B-cells, macrophages and dendritic cells.
BioGrid: 107379. 75 interactions.
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