Anti-CD8 Monoclonal Antibody (Clone:MEM-31)-PE/DyLight Conjugated

Product code: 30-2461

Clone name : MEM-31
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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100 tests
$494.00 

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Amount : 100 tests
Isotype : Mouse IgG2a
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD8A
Gene ID : 925
Uniprot ID : P01732
Alternative Name : T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL
Immunogen Information : Crude thymus membrane fraction.

The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Subcellular location: Secreted
Post transnational modification: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
Tissue Specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
BioGrid: 107364. 9 interactions.
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