Anti-CD79b Monoclonal Antibody (Clone:HM79)-PE Conjugated(Discontinued)

Product code: 30-2272

Clone name : HM79
Clonality : Monoclonal
Application : FACS, IP, WB, ICC
Reactivity : Mouse
Conjugate : PE

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Amount : 0.1 mg
Isotype : Hamster IgG2
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : Cd79b
Gene ID : 15985
Uniprot ID : P15530
Alternative Name : Cd79b, Igb
Immunogen Information : Purified CD79a/b (alpha/beta) dimers from WEHI231 cells
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Tissue Specificity: B-cells.
BioGrid: 200546. 2 interactions.
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