Anti-CD79b Monoclonal Antibody (Clone:HM79)-PE Conjugated(Discontinued)
Figure 1: Surface staining of CD79b in murine splenocytes with anti-CD79b (HM79) PE.
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| Amount : | 0.1 mg |
| Isotype : | Hamster IgG2 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| Tissue Specificity: | B-cells. |
| BioGrid: | 200546. 2 interactions. |
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