Anti-CD79b Monoclonal Antibody (Clone:CB3-1)-FITC Conjugated

Product code: 30-2089

Clone name : CB3-1
Clonality : Monoclonal
Application : FACS, IP, WB
Reactivity : Human
Conjugate : FITC

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100 tests
$433.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD79B
Gene ID : 974
Uniprot ID : P40259
Alternative Name : CD79B, B29, IGB
Immunogen Information : Fraction of Ig-associated molecules isolated from Ramos B cells
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Tissue Specificity: B-cells.
BioGrid: 107412. 110 interactions.
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