Anti-CD79a Monoclonal Antibody (Clone:HM57)

Product code: 30-1368

Clone name : HM57
Clonality : Monoclonal
Application : FACS, IHC, IHC-Fr
Reactivity : Human, Pig, Mouse, Rat, Bovine, Equine, Guinea pig, Opossum, Rabbit, Chicken

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD79A
Gene ID : 973
Uniprot ID : P11912
Alternative Name : CD79A, IGA, MB1
Immunogen Information : Synthetic peptide corresponding to amino acids 202-216 of human CD79a
CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Flow Cytometry Recommended dilution:5 µg/ml
Application note: intracellular staining
Immunohistochemistry Recommended dilution:10 µg/ml
Immunohistochemistry (frozen sections) Recommended dilution:10 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
Tissue Specificity: B-cells.
BioGrid: 107411. 53 interactions.
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