Anti-CD72 Monoclonal Antibody (Clone:3F3)-PE Conjugated
Figure 1: Surface staining of CD72 on human peripheral blood cells with anti-CD72 (3F3) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
| Subcellular location: | Membrane |
| Post transnational modification: | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity). |
| Tissue Specificity: | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| BioGrid: | 107409. 10 interactions. |
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