Anti-CD71 / Transferrin Receptor Monoclonal Antibody (Clone:MEM-75)

Product code: 30-1139

Clone name : MEM-75
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TFRC
Gene ID : 7037
Uniprot ID : P02786
Alternative Name : TFRC
Immunogen Information : NALM-6 human pre-B cell line

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.

Flow cytometry: Recommended dilution: 0.5-4 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
BioGrid: 112895. 98 interactions.
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