Anti-CD71 / Transferrin Receptor Monoclonal Antibody (Clone:MEM-75)-PE Conjugated

Product code: 30-2181

Clone name : MEM-75
Clonality : Monoclonal
Application : FACS, IP, ICC
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : TFRC
Gene ID : 7037
Uniprot ID : P02786
Alternative Name : TFRC
Immunogen Information : NALM-6 human pre-B cell line
CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
Subcellular location: Secreted
Post transnational modification: Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
BioGrid: 112895. 98 interactions.
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