Anti-CD7 Monoclonal Antibody (Clone:MEM-186) PE-PE-Cy™7
Figure 1: Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD7 (MEM-186) PE-Cy™7.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.
Flow Cytometry Recommended dilution: 2 µg/ml
Immunoprecipitation Western Blotting Application note: Non-reducing conditions. Immunohistochemistry Recommended dilution: 5 µg/ml
Positive tissue: spleen
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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