Anti-CD62P / P-selectin Monoclonal Antibody (Clone:AK4)-Low Endotoxin

Product code: 30-1645

Clone name : AK4
Clonality : Monoclonal
Application : FACS, IP, WB, ICC, Functional Assay
Reactivity : Human, Non-Human Primates

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : SELP
Gene ID : 6403
Uniprot ID : P16109
Alternative Name : SELP, GMRP, GRMP
Immunogen Information : Human platelets
CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

Flow Cytometry Recommended dilution:1.5 µg/ml
Immunoprecipitation Western Blotting Immunocytochemistry Functional Application Blocking

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
BioGrid: 112303. 9 interactions.
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