Anti-CD62L / L-Selectin Monoclonal Antibody (Clone:MEL-14)

CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).

Flow Cytometry Recommended dilution: 0.5 µg/ml
Immunoprecipitation Immunohistochemistry Immunohistochemistry (frozen sections) Immunocytochemistry Functional Application Blocking of cell adhesion

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane
Post transnational modification:	N-glycosylated.
Tissue Specificity:	Predominantly expressed in lymphoid tissue.

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