Anti-CD62L / L-Selectin Monoclonal Antibody (Clone:DREG56)

CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.

Flow Cytometry Recommended dilution:2 µg/ml
Immunoprecipitation Western Blotting Application note:non-reducing conditions
Immunohistochemistry (frozen sections) Functional Application Particularly effective in blocking of lymphocyte CD62L-mediated binding to peripheral lymph node HEV

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane
Post transnational modification:	N-glycosylated.
Tissue Specificity:	Expressed in B-cell lines and T-lymphocytes.
BioGrid:	112302. 13 interactions.

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